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Close Granulating Line for 5kg
XINGLE
Working principle：
5kg lab Close Granulating Line system is composed of a high shear granulator, wet granulator, fluid bed dryer (granulator), pneumatic vacuum feeder, dry granulator, hopper mixer and other feeding and discharging systems and connecting components. During the granulation process, powder materials are put into the wet granulator. All processes are operated in a closed environment, each device is compatible and smooth, and the final product is mixed and then tableted.
1. GHL mixing and granulator: first step to mix the different kinds dry powder, when the different powder mixed into uniform, and then to add the binder into GHL machine to made into the required damp material , final the cutting knife makes the wet material into graunles.
2. The wet granule will discharge into wet granulator (Conical Mill) from GHL to get required size.
3. After wet mill, the wet granule will be discharge and sucked into FL-5 fluid bed dryer for drying by negative pressure of FL-5 exhaust fan.
A.Closed linkage line (High shear granulator)
1.Comply with the GMP requirements of the pharmaceutical industry, suitable for new product trial production and medium and small batch production in laboratories and scientific research and teaching units, to ensure product quality and the standardization of the production process.
2. Equipped with a safety interlock device, it is safe and secure when in use, reducing the risk in the production process.
3. It adopts a horizontal body structure, with good overall rigidity, simple structure, convenient maintenance, and reduces equipment maintenance costs and time.
4. The main components are installed inside the body and covered with a 304 stainless steel casing. All parts that are in direct contact with the material are made of 304 stainless steel, which is corrosion-resistant and easy to clean, ensuring that the material is not contaminated.
5. The granulation process is closed, equipped with an elbow stirring paddle, which is at an angle of 15 degrees to the bottom of the pot. The material quickly generates a burst when mixed, and is equipped with 2-5 sets of cutting knives to improve the efficiency and quality of granulation.
6. The dual frequency converter is used to adjust the speed of the stirring paddle and the cutting knife, which can be accurately adjusted according to different materials and process requirements to improve production flexibility.
B. Closed linkage line (wet granulator)
1. Low heat generation during operation can reduce energy consumption and production costs; at the same time, less dust is beneficial to protect the environment and the health of operators.
2. The stator screen is made of stainless steel plate, which has high strength and corrosion resistance, is not easy to damage, and extends the service life of the equipment.
3. It can handle sticky, colloid, hot and wet materials, and is suitable for granulating materials of various properties, which improves the versatility and practicality of the equipment.
C. Closed linkage line (Fluid-Bed dryer)
Equipment application:
The material is suspended in a fluidized state under the action of clean hot air flow (negative pressure). Its surface is in full contact with the hot air, and is evenly heated, achieving the best heat exchange state, thus having extremely high efficiency. With a suitable spray system and further structural improvements, the fluidized bed becomes a multi-purpose process equipment that combines drying, granulation, and granulation.
This machine is equipped with a "top spray" system and is mainly used for mixing, drying, and granulation operations in the pharmaceutical, food, chemical and other industries.
The 5kg laboratory closed granulation line has many benefits when used in the laboratory, including:
Experimental accuracy:
1. Accurately control the amount of materials: The small batch processing capacity of 5kg allows the experimenter to accurately control the amount of various materials added, which is convenient for studying the granulation effect under different material ratios, and provides accurate data support for the development and optimization of the formula.
2. Ensure the repeatability of experimental results: Small batch production makes it easier to keep the conditions of each experiment consistent, reducing the operational errors and environmental factors caused by excessive material volume, thereby improving the repeatability and reliability of experimental results, and facilitating the accumulation and analysis of experimental data.
Product quality:
1. Strict closed environment: The entire granulation process is operated in a closed environment, which minimizes the contamination of materials by external impurities, dust and microorganisms, and ensures the purity and quality of the granulated products. In pharmaceutical laboratories, this is of great significance to ensure the safety and effectiveness of drugs, and avoids experimental result deviations or drug quality problems caused by contamination.
2. Stable granulation process: The smooth cooperation of various equipment ensures the stability of the granulation process. For example, the continuous operation from dry powder mixing to wet granulation and then to drying reduces the pauses and interferences in the intermediate links, making the produced particles more stable in terms of particle size distribution, density, fluidity, etc., which is conducive to subsequent experimental research and product development.
Safety assurance:
1. Reduce dust hazards: Closed operation can effectively control the diffusion of dust generated during the granulation process, reduce the irritation and damage of dust to the respiratory tract and skin of experimental personnel, and reduce the risk of occupational diseases.
2. Avoid material leakage: Prevent material leakage during the granulation process, avoid material waste and pollution to the laboratory environment, and also reduce the possibility of safety accidents such as fire and explosion caused by material leakage.
Working principle：
5kg lab Close Granulating Line system is composed of a high shear granulator, wet granulator, fluid bed dryer (granulator), pneumatic vacuum feeder, dry granulator, hopper mixer and other feeding and discharging systems and connecting components. During the granulation process, powder materials are put into the wet granulator. All processes are operated in a closed environment, each device is compatible and smooth, and the final product is mixed and then tableted.
1. GHL mixing and granulator: first step to mix the different kinds dry powder, when the different powder mixed into uniform, and then to add the binder into GHL machine to made into the required damp material , final the cutting knife makes the wet material into graunles.
2. The wet granule will discharge into wet granulator (Conical Mill) from GHL to get required size.
3. After wet mill, the wet granule will be discharge and sucked into FL-5 fluid bed dryer for drying by negative pressure of FL-5 exhaust fan.
A.Closed linkage line (High shear granulator)
1.Comply with the GMP requirements of the pharmaceutical industry, suitable for new product trial production and medium and small batch production in laboratories and scientific research and teaching units, to ensure product quality and the standardization of the production process.
2. Equipped with a safety interlock device, it is safe and secure when in use, reducing the risk in the production process.
3. It adopts a horizontal body structure, with good overall rigidity, simple structure, convenient maintenance, and reduces equipment maintenance costs and time.
4. The main components are installed inside the body and covered with a 304 stainless steel casing. All parts that are in direct contact with the material are made of 304 stainless steel, which is corrosion-resistant and easy to clean, ensuring that the material is not contaminated.
5. The granulation process is closed, equipped with an elbow stirring paddle, which is at an angle of 15 degrees to the bottom of the pot. The material quickly generates a burst when mixed, and is equipped with 2-5 sets of cutting knives to improve the efficiency and quality of granulation.
6. The dual frequency converter is used to adjust the speed of the stirring paddle and the cutting knife, which can be accurately adjusted according to different materials and process requirements to improve production flexibility.
B. Closed linkage line (wet granulator)
1. Low heat generation during operation can reduce energy consumption and production costs; at the same time, less dust is beneficial to protect the environment and the health of operators.
2. The stator screen is made of stainless steel plate, which has high strength and corrosion resistance, is not easy to damage, and extends the service life of the equipment.
3. It can handle sticky, colloid, hot and wet materials, and is suitable for granulating materials of various properties, which improves the versatility and practicality of the equipment.
C. Closed linkage line (Fluid-Bed dryer)
Equipment application:
The material is suspended in a fluidized state under the action of clean hot air flow (negative pressure). Its surface is in full contact with the hot air, and is evenly heated, achieving the best heat exchange state, thus having extremely high efficiency. With a suitable spray system and further structural improvements, the fluidized bed becomes a multi-purpose process equipment that combines drying, granulation, and granulation.
This machine is equipped with a "top spray" system and is mainly used for mixing, drying, and granulation operations in the pharmaceutical, food, chemical and other industries.
The 5kg laboratory closed granulation line has many benefits when used in the laboratory, including:
Experimental accuracy:
1. Accurately control the amount of materials: The small batch processing capacity of 5kg allows the experimenter to accurately control the amount of various materials added, which is convenient for studying the granulation effect under different material ratios, and provides accurate data support for the development and optimization of the formula.
2. Ensure the repeatability of experimental results: Small batch production makes it easier to keep the conditions of each experiment consistent, reducing the operational errors and environmental factors caused by excessive material volume, thereby improving the repeatability and reliability of experimental results, and facilitating the accumulation and analysis of experimental data.
Product quality:
1. Strict closed environment: The entire granulation process is operated in a closed environment, which minimizes the contamination of materials by external impurities, dust and microorganisms, and ensures the purity and quality of the granulated products. In pharmaceutical laboratories, this is of great significance to ensure the safety and effectiveness of drugs, and avoids experimental result deviations or drug quality problems caused by contamination.
2. Stable granulation process: The smooth cooperation of various equipment ensures the stability of the granulation process. For example, the continuous operation from dry powder mixing to wet granulation and then to drying reduces the pauses and interferences in the intermediate links, making the produced particles more stable in terms of particle size distribution, density, fluidity, etc., which is conducive to subsequent experimental research and product development.
Safety assurance:
1. Reduce dust hazards: Closed operation can effectively control the diffusion of dust generated during the granulation process, reduce the irritation and damage of dust to the respiratory tract and skin of experimental personnel, and reduce the risk of occupational diseases.
2. Avoid material leakage: Prevent material leakage during the granulation process, avoid material waste and pollution to the laboratory environment, and also reduce the possibility of safety accidents such as fire and explosion caused by material leakage.
